There are many advantages to the rectal administration of cannabis compared to the other routes. If the oral route is disallowed due to oral intake restrictions frequently required both before and after surgery, or if the oral route is impaired due to e.g. vomiting, injured jaw or throat, or gastrointestinal difficulties, it is still be possible to administer Cannabis rectally. CBD cannabis suppositories makes it possible to avoid drug degradation in the gastrointestinal tract and bypass first-pass metabolism in the liver. This allows the cannabinoids to reach the blood in much higher concentrations.
Furthermore, the rectal administration method allows for a greater proportion of CBD to eventually reach the bloodstream. This form for administration offers a much faster uptake than oral administration (approximately 10 minutes, on average). The speed and reliability of CBD suppositories and their uptake combined with their circumvention of many issues surrounding both ingestion and inhalation make rectal applications an excellent addition to both new and pre-existing therapeutic regimens.
With CBD suppositories, initial effects will most often be noticed within 10-15 minutes after application, and these effects will usually last 4-8 hours depending on the physiology and tolerance for cannabis of the individual.
However, there are several issues that can slow the absorption of CBD suppositories from the rectum to the bloodstream. Diarrhea, fecal matter and tumors or cysts on the rectum wall can slow or prevent the cannabinoids from reaching the rectal wall and being absorbed. Rectal dehydration can also drastically reduce the effectiveness of cannabis suppositories. Staying well hydrated by maintaining a healthy consumption of both water and electrolytes may prevent this. However, specific medical condition may also cause rectal dehydration, in which case the solution may not be as simple. In case of concern, medical professionals should be consulted.
CBD suppositories can be used to refine existing therapeutic regimens to greater effects. People, who have been prevented from using cannabis due to inability to administer via ingestion or inhalation, can potentially derive benefit from cannabis for the first time by using cannabis suppositories